For 400,000 years, humans were good at hunter-gathering. Which meant we had to know all of the terrain around us, we had to know all the foods, poisons, animals, enemies. And then we would move to a new terrain. Change was part of our DNA.
But for the past 10,000 years (a blip in evolutionary time), we had to specialize and be good at one thing and in one place.
Nobody told evolution this.
So our bodies break down, our minds get sick, we need all sorts of medications, we die. Evolution wants us to constantly change.